K. Naga Rani*, P. Venkateswara Rao, K. Sirisha, P. Vijaya Lakshmi, Mahimudh Arief.
Abstract:
The objective of the present study was to evaluate the anti-depressant activity of Zizipus jujube. Ziziphus jujuba (Rhamnaceae) is a traditional medicinal plant known as jujube. This plant has been used for the treatment of a variety of diseases. This study was done to evaluate the possible antidepressant effect of Ziziphus jujuba pulp extract (ZJPE) using tail suspension test (TST) & forced swim test (FST). Group-I (control) received normal saline (1ml/100gm), Group-II, III & IV received ZJPE in doses of 20, 30, 40 mg/kg orally (P.O.) respectively. Group V (positive control) received Imipramine at doses of 15mg/kg p.o. respectively. Drug treatment was given for seven & fourteen successive days and after 60 minutes interval last dose of drug or standard the immobility period was recorded. ZJPE produced significant antidepressant like effect at dose of 20, 30& 40 mg/kg administered for 7 & 14 consecutive days as indicated by reduction in immobility times of rat in TST & FST (P<0.05). The efficacy of ZJPE at 30mg/kg was found to be comparable to that of Imipramine at doses of 15mg/kg.