D. Vyshnavi*, G. Swapna, A. Mary Prasanthi, G. Ramakrishna
Abstract:
The Eprosartan is a selective ACE-II blocking agent which is used in the treatment of hypertension. In this study Eprosartan Floating tablets were prepared by using different polymers like HPMCK4M, HPMCK15M, HPMCK100M and CARBOPOL and HPC. Fifteen formulations of floating tablets of Eprosartan were developed by direct compression technique. The F9 formulation was found to be best of all the trials. The best formulation F9 can successfully be employed as a controlled release floating drug delivery system. The floating tablets can control the fluctuations in the plasma drug concentration, increase the gastric residence time and eventually improve the bioavailability of the drug. The FTIR study ruled out the drug-polymer interaction.