Tejaswi Koppula*
Abstract:
In this study, jackfruit seed flour was prepared and starch was extracted using different extraction conditions such as (distilled water method and alkaline method). The results showed that distilled water method gave highest yield compared to alkali method. Starch identification tests were carried out on isolated material as confirmation tests. To evaluate the binding properties of seed starch, using Paracetamol as model drug tablets were prepared by wet granulation method. Micromeritic properties for granules and powder mixture give good and passable flow properties. Post compression studies also give good results and the prepared tablets were also evaluated for in vitro drug release studies which were then compared with the marketed tablets P-250 apex. The r2 values of regression plots for First order and Zero order were considered for both the binding (F1, F2, F3) and disintegrating (S1, S2, S3) properties, r2 values for the First order was found to be more than Zero order. Hence it was confirmed that the drug release follows first order kinetics. Therefore the release rate in formulations depends on concentration or amount of drug incorporated. Compatibility studies were conducted by FTIR spectrometer and concluded that there was no interaction between seed starch and drug. The overall results showed that jackfruit seed might be used good source of starch as well as extracted starch could be used as binding agent and disintegrating agent in pharmaceutical formulations.